Swiss Pharmaceuticals 5-Amino-1MQ 60 caps

What is 5-AMINO-1MQ?

5-amino-1MQ is a small molecule drug that works by blocking the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays an important role in metabolism and energy and is active mainly in adipose tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the "longevity gene" for its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration and cancer.

Simply put

This means that 5-amino-1MQ allows your body to burn fat for energy while preferentially maintaining muscle mass. 5-amino-1MQ is safe and effective for reversing and preventing diet-induced obesity. It is a potentially better treatment option for individuals with (or at risk of) type 2 diabetes and other metabolic comorbidities of obesity. Moreover, the activation of SIRT1 through increased NAD+ suggests that 5-amino-1MQ is a good choice for patients who want to develop
a comprehensive anti-aging protocol.

There is a critical need for new drugs with mechanisms of action that reduce the burden of obesity, osteoarthritis, cardiovascular disease, cancer, Parkinson's disease, kidney disease, metabolic disorders, and other associated chronic metabolic comorbidities.

Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme with a recently identified role in cellular metabolism and energy homeostasis. Studies show that this enzyme slows down the process by which our body metabolizes fat cells. Most people have trouble losing weight, and when this enzyme is elevated, it becomes more difficult to shed pounds of excess fat. Being overweight leads to an increase in the NNMT enzyme, which leads to a slowdown in fat metabolism, which leads to excessive weight gain. It's a vicious cycle. Research indicates that the potent NNMT inhibitor "5-amino-1mq" significantly reduced body weight and white fat mass, reduced adipocyte size, and reduced total plasma cholesterol.

These findings support the development of small molecule NNMT inhibitors as therapeutics for the reversal of diet-induced obesity and validate NNMT as a viable target for the treatment of obesity and related metabolic conditions.

Advantages:

NNMT inhibitors as therapy to reverse diet-induced obesity.
NNMT is a valid target for the treatment of obesity and related metabolic diseases.
Prevent adipogenesis and reverse diet-induced obesity. NNMT expression is upregulated in white adipose tissue (WAT). It has significantly higher activity in WAT compared to activity in brown adipose tissue, liver and lung.
NNMT inhibitors had no effect on food intake. However, they demonstrated significant reductions in body weight, WAT weight, adipocyte size, and cholesterol levels with negligible … (text ended here in provided copy)…